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36 Recent evidence demonstrates that LOS elicits TNF О±, IL 1ОІ, IL 6, and IL 8 secretion from urethral epithelial cells buying generic cialis online safe In certain embodiments of a compounds of Formula 1, R can be a chemotherapeutic moiety selected from N CH CH R, CH N CH CH R, N O CH CH R, CH N O CH CH R, N O CH CH R CH CH R, CH N O CH CH R CH CH R, O N CH CH R, CH O N CH CH R, CO N CH CH R, CH CO N CH CH R, O CO N CH CH R, and CH O CO N CH CH R, wherein each R is independently selected from Cl, Br, I, OSO CH, OSO CF, and hydroxyl OH; R can be selected from hydrogen, halogen, N R, N O R, N R OR, NO, NO, CN, COOR, CON R, OH, C alkyl, C alkoxy, C alkylsulfanyl, C alkylsulfinyl, C alkylsulfonyl, C heteroalkyl, C heteroalkoxy, C fluoroalkyl, C fluoroalkoxy, C cycloalkyl, C cycloalkyloxy, and C cycloalkylalkyl; wherein each R can be independently selected from hydrogen, deuterio, C alkyl and C alkoxy, or two geminal R together with the nitrogen to which they are bonded form a 3 to 6 membered heterocyclic ring; each of R, R, and R can be hydrogen; R can be selected from COOH, COOR, S O OH, P O OH H, and 1H tetrazol yl, wherein R is selected from C alkyl; each R can be independently selected from hydrogen, methyl, hydroxyl, and fluoro; R can be selected from hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, isobutyl, cyclobutyl, tert butyl, C alkoxy, C fluoroalkyl, and C fluoroalkoxy; and L can be selected from a bond, CH, C OH H, CHCH, C CH, CF, O, SO, NR, CO, CH CH, CH CHCH, CHCH CH, CH CHOH, CHOH CH, CH CF, CF CH, CO NR, NR CO, CH NR, NR CH, CH O, O CH, CH S, S CH, CH SO, SO CH, CH CO, and CO CH, wherein R is selected from hydrogen, methyl, and ethyl
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